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Article

Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.

Journal of molecular biology - 30 Mar 2012

Heng Xiao, Kharytonchyk Siarhei, Garcia Eric L, Lu Kun, Divakaruni Sai Sachin, LaCotti Courtney, Edme Kedy, Telesnitsky Alice, Summers Michael F

Abstract excerpt

Assembly of human immunodeficiency virus type 1 (HIV-1) particles is initiated in the cytoplasm by the formation of a ribonucleoprotein complex comprising the dimeric RNA genome and a small number of viral Gag polyproteins. Genomes are recognized by the nucleocapsid (NC) domains of Gag, which interact with packaging elements believed to be located primarily within the 5'-leader (5'-L) of the viral RNA. Recent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22306406
DOI: 10.1016/j.jmb.2012.01.033
PMCID: PMC3296369

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