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Definition of the components required for selective packaging of coronavirus genomic RNA

21 Aug 2025

Abstract excerpt

Most cytoplasmic RNA viruses have evolved mechanisms to identify their genomic RNA (gRNA) as the sole RNA species to be packaged into assembled virions. Coronaviruses exhibit highly selective packaging of their gRNA, in spite of the presence of a large excess of subgenomic viral and host RNA in infected cells. Failure to accomplish this selectivity does not impair virion assembly but renders the virus vulnerable...

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PMID: 40838885
DOI: 10.1073/pnas.2513552122

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