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Article

An RNA structural switch regulates diploid genome packaging by Moloney murine leukemia virus.

Journal of molecular biology - 12 Feb 2010

Miyazaki Yasuyuki, Garcia Eric L, King Steven R, Iyalla Kilali, Loeliger Kelsey, Starck Patrice, Syed Sameera, Telesnitsky Alice, Summers Michael F

Abstract excerpt

Retroviruses selectively package two copies of their RNA genomes via mechanisms that have yet to be fully deciphered. Recent studies with small fragments of the Moloney murine leukemia virus (MoMuLV) genome suggested that selection may be mediated by an RNA switch mechanism, in which conserved UCUG elements that are sequestered by base-pairing in the monomeric RNA become exposed upon dimerization to allow binding...

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Identifiers

PMID: 19931283
DOI: 10.1016/j.jmb.2009.11.033
PMCID: PMC2836482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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