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Article

Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging.

RNA (New York, N.Y.) - 1 Aug 2013

Webb Joseph A, Jones Christopher P, Parent Leslie J, Rouzina Ioulia, Musier-Forsyth Karin

Abstract excerpt

Despite the vast excess of cellular RNAs, precisely two copies of viral genomic RNA (gRNA) are selectively packaged into new human immunodeficiency type 1 (HIV-1) particles via specific interactions between the HIV-1 Gag and the gRNA psi (ψ) packaging signal. Gag consists of the matrix (MA), capsid, nucleocapsid (NC), and p6 domains. Binding of the Gag NC domain to ψ is necessary for gRNA packaging, but the...

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Identifiers

PMID: 23798665
DOI: 10.1261/rna.038869.113
PMCID: PMC3708528

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Source receipt: pubmed, retrieved 7 Sept 2026.

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