Article
A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening.
PloS one - 1 Jan 2021
Sun Qing, Pastor Larry, Du Jinwei, Powell Michael J, Zhang Aiguo, Bodmer Walter, Wu Jianzhong, Zheng Shu, Sha Michael Y
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Early detection is critical to reduce CRC morbidity and mortality. In order to meet this need, we developed a molecular clamping assay called the ColoScape TM assay for early colorectal cancer diagnostics. METHODS: Nineteen mutations in four genes (APC, KRAS, BRAF and CTNNB1) associated with early events in CRC pathogenesis...
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