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Article

Functional significance of the Toll-like receptor 4 promoter gene polymorphisms in the Chinese Han population.

Critical care medicine - 1 May 2010

Chen Kehong, Wang Yong-tang, Gu Wei, Zeng Ling, Jiang Dong-po, Du Ding-yuan, Hu Ping, Duan Zhao-xia, Liu Qing, Huang S N, Jiang Jian-xin

Abstract excerpt

OBJECTIVE: Toll-like receptor 4 is an important signaling receptor for lipopolysaccharide in mammals, and the variation of the promoter may affect the activity of toll-like receptor 4 expression. Although 12 single nucleotide polymorphisms have been identified in the toll-like receptor 4 promoter, little is known about the functional significance of these single nucleotide polymorphisms. DESIGN: Genetic...

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PMID: 20228685
DOI: 10.1097/CCM.0b013e3181d8ad12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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