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Article

Comprehensive Prediction Analysis of Novel Noncoding Regulatory Variants Identified in the MicroRNA Binding Regions in Complement System Genes.

International journal of molecular sciences - 30 Jun 2026

Shadid Anthony, Rich Haydn E, Hok Kathryn D, Doursout Marie-Francoise, Restrepo Marcos I, Banda Nirmal K, Gunamalai Lavanya, Shivshankar Pooja

Abstract excerpt

The complement system is a central component of innate immunity that coordinates host defense, immune surveillance, and inflammatory responses through tightly regulated proteolytic cascades. Genetic variation within complement genes contributes substantially to interindividual differences in complement activity and disease susceptibility. While coding variants directly alter complement protein structure and...

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PMID: 42450148
DOI: 10.3390/ijms27135877
PMCID: PMC13361139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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