Article
Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults.
Alzheimer's research & therapy - 10 Apr 2023
Malek-Ahmadi Michael, Su Yi, Ghisays Valentina, Luo Ji, Devadas Vivek, Chen Yinghua, Lee Wendy, Protas Hillary, Chen Kewei, Zetterberg Henrik, Blennow Kaj, Caselli Richard J, Reiman Eric M
Abstract excerpt
BACKGROUND: Plasma neurofilament light (NfL) is an indicator of neurodegeneration and/or neuroaxonal injury in persons with Alzheimer's disease (AD) and a wide range of other neurological disorders. Here, we characterized and compared plasma NfL concentrations in cognitively unimpaired (CU) late-middle-aged and older adults with two, one, or no copies of the APOE ε4 allele, the major genetic risk factor for AD....
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