Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer's disease.

doi:10.1002/alz.12248

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Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2021

Guzmán-Vélez Edmarie, Zetterberg Henrik, Fox-Fuller Joshua T, Vila-Castelar Clara, Sanchez Justin S, Baena Ana, Garcia-Ospina Gloria, Aguillon David, Pardilla-Delgado Enmanuelle, Gatchel Jennifer R, Sperling Reisa A, Johnson Keith, Reiman Eric M, Blennow Kaj, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

BACKGROUND: Neurofilament light (NfL) is a promising biomarker of early neurodegeneration in Alzheimer's disease (AD). We examined whether plasma NfL was associated with in vivo amyloid beta and tau, and cognitive performance in non-demented presenilin-1 (PSEN1) E280A mutation carriers. METHODS: Twenty-five mutation carriers and 19 non-carriers (age range: 28 to 49 years) were included in this study. Participants...

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PMID: 33527648
DOI: 10.1002/alz.12248
PMCID: PMC8158654

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Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer's disease.PMID 33527648Read ↗

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