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Toxic Epidermal Necrolysis Observed in a Patient With the HLA-B*1502 Treated With Levofloxacin.

Clinical therapeutics - 1 Dec 2024

Wang Xiufang, Cheng Gangying, Liang Xiaofang, Yang Junhui, Deng Aiping, Chen Dan, Liu Chao, Gao Ying, Li Juyi

Abstract excerpt

PURPOSE: To determine the relationship between HLA-B gene mutations and levofloxacin-induced toxic epidermal necrolysis (TEN). METHODS: A 71-year-old Chinese woman developed TEN after oral administration of solifenacin (5 mg) and levofloxacin (0.5 g) for cystitis. HLA-B*5801 and HLA-B*1502 alleles were detected using real-time PCR. FINDINGS: After supportive therapy (antiallergic treatments, plasma exchange, etc)...

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PMID: 39353751
DOI: 10.1016/j.clinthera.2024.09.014

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