Article
Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients.
European journal of clinical pharmacology - 1 Sept 2011
Zhang Yan, Wang Jin, Zhao Li-Mei, Peng Wei, Shen Guo-Qing, Xue Ling, Zheng Xiao-Xian, He Xiao-Jing, Gong Chun-Yan, Miao Li-Yan
Abstract excerpt
PURPOSE: The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population. METHODS: HLA-B*1502 genotyping with sequence-specific primer polymerase chain reaction (PCR-SSP) and PCR-sequencing based typing (PCR-SBT) was performed on 17 CBZ-induced SJS/TEN patients, 21 CBZ-tolerant controls, and 185 healthy controls recruited during...
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