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Investigating the association of Lamotrigine and Phenytoin-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population.

Experimental dermatology - 1 Feb 2021

Sabourirad Sara, Mortezaee Reza, Mojarad Majid, Eslahi Atieh, Shahrokhi Yahya, Kiafar Bita, Jarahi Lida, Afkhami Ardakani Saman, Farrokhi Shima

Abstract excerpt

Previous studies have found an association between HLA-B*1502 allele and lamotrigine-induced Stevens-Johnson syndrome (SJS)/ toxic epidermal necrosis (TEN) spectrum in Han Chinese populations. This study aims to investigate the association between HLA-B*1502 and lamotrigine- or phenytoin- induced SJS/TEN in an Iranian population. The medical records of twenty-eight lamotrigine-induced SJS/TEN patients and...

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PMID: 33217035
DOI: 10.1111/exd.14240

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HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies.Semantic proximity Read ↗

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