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Article

HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Pharmacogenomics - 1 Jun 2010

Kim Sae-Hoon, Kim Myunghwa, Lee Kyung Wha, Kim Sang-Heon, Kang Hye-Ryun, Park Heung-Woo, Jee Young-Koo

Abstract excerpt

AIMS: The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports. This study examined the disease-associated B*59 allele and investigated the association of these diseases with other HLA class I alleles. METHODS: We performed high-resolution...

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Identifiers

PMID: 20504258
DOI: 10.2217/pgs.10.54

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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