Article
Renin-angiotensin blockade ameliorates the progression of glomerular injury in podocyte-specific Ctcf knockout mice.
Nephrology (Carlton, Vic.) - 1 Dec 2024
Fujioka Keisuke, Nagai Takashi, Hattori Tomoki, Kagami Shoji, Yasutomo Koji, Galjart Niels, Hirayama Teruyoshi, Kawachi Hiroshi, Urushihara Maki
Abstract excerpt
AIM: Several studies have shown that the progression of proteinuria and renal tissue injury is associated with activation of the intrarenal renin-angiotensin system (RAS). CCCTC-binding factor (CTCF) is a DNA-binding factor that plays an essential role in the regulation of gene expression. In the present study, we aimed to investigate the phenotypic effects of CTCF deficiency in podocytes. METHODS: Angiotensin II...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.