Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.

doi:10.1007/s00125-024-06277-3

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Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.

Diabetologia - 1 Dec 2024

Liu Shuai, Zhu Jingjing, Zhong Hua, Wu Chong, Xue Haoran, Darst Burcu F, Guo Xiuqing, Durda Peter, Tracy Russell P, Liu Yongmei, Johnson W Craig, Taylor Kent D, Manichaikul Ani W, Goodarzi Mark O, Gerszten Robert E, Clish Clary B, Chen Yii-Der Ida, Highland Heather, Haiman Christopher A, Gignoux Christopher R, Lange Leslie, Conti David V, Raffield Laura M, Wilkens Lynne, Marchand Loïc Le, North Kari E, Young Kristin L, Loos Ruth J, Buyske Steve, Matise Tara, Peters Ulrike, Kooperberg Charles, Reiner Alexander P, Yu Bing, Boerwinkle Eric, Sun Quan, Rooney Mary R, Echouffo-Tcheugui Justin B, Daviglus Martha L, Qi Qibin, Mancuso Nicholas, Li Changwei, Deng Youping, Manning Alisa, Meigs James B, Rich Stephen S, Rotter Jerome I, Wu Lang

Abstract excerpt

AIMS/HYPOTHESIS: Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To better understand the role played by proteins in type 2 diabetes aetiology across diverse populations, we conducted a large proteome-wide association study using genetic instruments across four racial and ethnic groups: African; Asian; Hispanic/Latino; and European. METHODS:...

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PMID: 39349773
DOI: 10.1007/s00125-024-06277-3
PMCID: PMC11963907

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