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Article

Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.

Chemical research in toxicology - 21 Oct 2024

Ford Megan, Thomson Paul J, Snoeys Jan, Meng Xiaoli, Naisbitt Dean J

Abstract excerpt

Elevations in hepatic enzymes were detected in several trial patients exposed to the Alzheimer's drug atabecestat, which resulted in termination of the drug development program. Characterization of hepatic T-lymphocyte infiltrates and diaminothiazine (DIAT) metabolite-responsive, human leukocyte antigen (HLA)-DR-restricted, CD4+ T-lymphocytes in the blood of patients confirmed an immune pathogenesis. Patients...

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Identifiers

PMID: 39348529
DOI: 10.1021/acs.chemrestox.4c00262
PMCID: PMC11497358

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CD4

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