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Article

[Recent Insights into HLA-dependent Idiosyncratic Liver Injury].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2026

Aoki Shigeki, Kazaoka Akira, Ito Kousei

Abstract excerpt

Idiosyncratic drug-induced liver injury (iDILI) is a rare but serious adverse reaction that occurs only in a small subset of individuals. Traditionally, drug-induced liver injury has been studied primarily through the lens of hepatocellular toxicity; however, this approach fails to explain the unpredictable nature of iDILI, which often evades detection in preclinical models. Recent studies have shifted the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41621894
DOI: 10.1248/yakushi.25-00145-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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