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Article

HLA Class-II‒Restricted CD8+ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients.

The Journal of investigative dermatology - 1 Oct 2021

Zhao Qing, Almutairi Mubarak, Tailor Arun, Lister Adam, Harper Nicolas, Line James, Meng Xiaoli, Pratoomwun Jirawat, Jaruthamsophon Kanoot, Sukasem Chonlaphat, Sun Yonghu, Sun Lele, Ogese Monday O, MacEwan David J, Pirmohamed Munir, Liu Jianjun, Ostrov David A, Liu Hong, Zhang Furen, Naisbitt Dean J

Abstract excerpt

HLA-B∗13:01 is associated with dapsone (DDS)-induced hypersensitivity, and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (nitroso dapsone [DDS-NO]). However, there is a need to define the importance of the HLA association in the disease pathogenesis. Thus, DDS- and DDS-NO‒specific CD8+ T-cell clones (TCCs) were generated from hypersensitive patients expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33798536
DOI: 10.1016/j.jid.2021.03.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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