Article
Deletion of miR-33, a regulator of the ABCA1-APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2024
Tate Mason, Wijeratne H R Sagara, Kim Byungwook, Philtjens Stéphanie, You Yanwen, Lee Do-Hun, Gutierrez Daniela A, Sharify Daniel, Wells Megan, Perez-Cardelo Magdalena, Doud Emma H, Fernandez-Hernando Carlos, Lasagna-Reeves Cristian, Mosley Amber L, Kim Jungsu
Abstract excerpt
INTRODUCTION: Rare variants in ABCA1 increase the risk of developing Alzheimer's disease (AD). ABCA1 facilitates the lipidation of apolipoprotein E (apoE). This study investigated whether microRNA-33 (miR-33)-mediated regulation of this ABCA1-APOE pathway affects phenotypes of an amyloid mouse model. METHODS: We generated mir-33+/+;APP/PS1 and mir-33-/-;APP/PS1 mice to determine changes in amyloid pathology using...
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