Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development

Abstract excerpt

Rationale: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient mice are predisposed to the development of obesity and metabolic dysfunction. The proatherogenic effects of miR-33 are thought to be in large part because of its repression of macrophage cholesterol efflux, through targeting of Abca1 (ATP-binding cassette subfamily A member 1). However, targeting of other factors may also...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cholesterol and Lipid Metabolism
• Share to Circular RNAs in diseases
• Share to MicroRNA in disease regulation