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Article

Reconstructing oral cavity tumor evolution through brush biopsy.

Scientific reports - 30 Sept 2024

John Evit, Lesluyes Tom, Baker Toby M, Tarabichi Maxime, Gillenwater Ann, Wang Jennifer R, Van Loo Peter, Zhao Xiao

Abstract excerpt

Oral potentially malignant disorders (OPMDs) with genomic alterations have a heightened risk of evolving into oral squamous cell carcinoma (OSCC). Currently, genomic data are typically obtained through invasive tissue biopsy. However, brush biopsy is a non-invasive method that has been utilized for identifying dysplastic cells in OPMD but its effectiveness in reflecting the genomic landscape of OPMDs remains...

Topics

Humans
Mouth Neoplasms
Biopsy
DNA Copy Number Variations
Polymorphism, Single Nucleotide
Carcinoma, Squamous Cell
Pilot Projects
Male
Middle Aged
Genomics
Female

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Mouth Mucosa

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Identifiers

PMID: 39343812
DOI: 10.1038/s41598-024-72946-3
PMCID: PMC11439926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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