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Article

Discrepancy Between Clinical Diagnosis and Whole-exome Sequencing-based Clonality Analysis of Synchronous Multiple Oral Cancers.

Anticancer research - 1 Feb 2021

Nishii Naoto, Hirotsu Yosuke, Koida Nami, Takahashi Yukinobu, Takagawa Yuki, Amemiya Kenji, Oyama Toshio, Mochizuki Hitoshi, Furusawa-Nishii Emi, Harada Hiroyuki, Omata Masao

Abstract excerpt

BACKGROUND/AIM: The definition of multiple oral cancers is based on the distances between the tumors. However, it is not possible to accurately predict tumor origins based only on clinical criteria. PATIENTS AND METHODS: We performed whole-exome sequencing (WES) to analyze the genetic alterations in five tumors of two patients who underwent surgery in our hospital. RESULTS: In case 1, the distances between tumors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33517312
DOI: 10.21873/anticanres.14859

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