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Article

The clonal relationships between pre-cancer and cancer revealed by ultra-deep sequencing.

The Journal of pathology - 1 Nov 2015

Wood Henry M, Conway Caroline, Daly Catherine, Chalkley Rebecca, Berri Stefano, Senguven Burcu, Stead Lucy, Ross Lisa, Egan Philip, Chengot Preetha, Graham Jennifer, Sethi Neeraj, Ong Thian K, High Alec, MacLennan Kenneth, Rabbitts Pamela

Abstract excerpt

The study of the relationships between pre-cancer and cancer and identification of early driver mutations is becoming increasingly important as the value of molecular markers of early disease and personalised drug targets is recognized, especially now the extent of clonal heterogeneity in fully invasive disease is being realized. It has been assumed that pre-cancerous lesions exhibit a fairly passive progression...

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Identifiers

PMID: 26096211
DOI: 10.1002/path.4576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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