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Article

Intratumoural heterogeneity and clone evolution of oral squamous cell carcinoma.

Molecular carcinogenesis - 1 Nov 2021

Wang Lin, Wang Xinmiao, Jia Yulin, Guo Fengyuan, Zhengjun Shang, Shao Zhe

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Our study uses multipoint materials to explore the heterogeneity and metastasis mechanism of OSCC to find more accurate molecular markers and new therapeutic targets. By using whole-exome capture and sequencing and tumor evolution analysis, we found that most clone-driven mutations were located in the branches of tumor phylogenetic...

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Identifiers

PMID: 34432915
DOI: 10.1002/mc.23341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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