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Article

CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.

PloS one - 1 Jan 2016

Kar Adwitiya, Beam Haley, Borror Megan B, Luckow Michael, Gao Xiaoli, Rea Shane L

Abstract excerpt

Ubiquinone (Qn) functions as a mobile electron carrier in mitochondria. In humans, Q biosynthetic pathway mutations lead to Q10 deficiency, a life threatening disorder. We have used a Saccharomyces cerevisiae model of Q6 deficiency to screen for new modulators of ubiquinone biosynthesis. We generated several hypomorphic alleles of coq7/cat5 (clk-1 in Caenorhabditis elegans) encoding the penultimate enzyme in Q...

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PMID: 27603010
DOI: 10.1371/journal.pone.0162165
PMCID: PMC5014327

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Source receipt: pubmed, retrieved 7 Sept 2026.

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CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.PMID 27603010Read ↗

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