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Article

CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.

PloS one - 1 Jan 2016

Kar Adwitiya, Beam Haley, Borror Megan B, Luckow Michael, Gao Xiaoli, Rea Shane L

Abstract excerpt

Ubiquinone (Qn) functions as a mobile electron carrier in mitochondria. In humans, Q biosynthetic pathway mutations lead to Q10 deficiency, a life threatening disorder. We have used a Saccharomyces cerevisiae model of Q6 deficiency to screen for new modulators of ubiquinone biosynthesis. We generated several hypomorphic alleles of coq7/cat5 (clk-1 in Caenorhabditis elegans) encoding the penultimate enzyme in Q...

Topics

Alleles
Cardiolipins
Genes, Suppressor
Lysophospholipids
Models, Biological
Mutation
Phospholipases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Suppression, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27603010
DOI: 10.1371/journal.pone.0162165
PMCID: PMC5014327

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CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.PMID 27603010Read ↗

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