Article
The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.
The Journal of biological chemistry - 30 Dec 2005
Barros Mario H, Johnson Alisha, Gin Peter, Marbois Beth N, Clarke Catherine F, Tzagoloff Alexander
Abstract excerpt
Deletion of the Saccharomyces cerevisiae gene YOL008W, here referred to as COQ10, elicits a respiratory defect as a result of the inability of the mutant to oxidize NADH and succinate. Both activities are restored by exogenous coenzyme Q2. Respiration is also partially rescued by COQ2, COQ7, or COQ8/ABC1, when these genes are present in high copy. Unlike other coq mutants, all of which lack Q6, the coq10 mutant...
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