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The impact of vitamin D in breast cancer: genomics, pathways, metabolism

13 Jun 2014

Abstract excerpt

Nuclear receptors exert profound effects on mammary gland physiology and have complex roles in the etiology of breast cancer. In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR) interacts with its ligand 1α,25(OH)2D3 to modulate the normal mammary epithelial cell genome and subsequent phenotype. Observational studies suggest that vitamin D...

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PMID: 24982636
DOI: 10.3389/fphys.2014.00213

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