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Article

Impact of donor NKG2D and MICA gene polymorphism on clinical outcomes of adult and paediatric allogeneic cord blood transplantation for malignant diseases.

European journal of haematology - 1 Jul 2024

Cox Steven T, Patterson Warren, Duggleby Richard, Jones Owen J R, Madrigal J Alejandro, Querol Sergi, Salvador Francesc Rudilla, Mata Maria Jose Herrero, Volt Fernanda, Gluckman Éliane, Szydlo Richard, Danby Robert D, Hernandez Diana

Abstract excerpt

OBJECTIVES: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated...

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Share to Cord Blood Stem Cell Transplantation
Share to Graft Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cell Transplantation

Share to Histocompatibility Antigens Class I

Share to NK Cell Lectin-Like Receptor Subfamily K

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Identifiers

PMID: 38511389
DOI: 10.1111/ejh.14202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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