Article
BLAST: a globally applicable and molecularly versatile survival model for chronic myelomonocytic leukemia.
Blood - 14 Aug 2025
Tefferi Ayalew, Fathima Saubia, Abdelmagid Maymona, Alsugair Ali Khalid A, Aperna Fnu, Rezasoltani Mahsa, Yousuf Muhammad, Natu Anuya, Csizmar Clifford M, Gurney Mark, Lasho Terra L, Finke Christy M, Kangal-Shamanna Rashmi, Hammond Danielle, Chien Kelly, Bazinet Alexandre, DiNardo Courtney D, Kadia Tapan M, Mangaonkar Abhishek A, Daver Naval, Pardanani Animesh, Borthakur Gautam, Zepeda-Mendoza Cinthya, Reichard Kaaren K, He Rong, Loghavi Sanam, Passamonti Francesco, Ravandi Farhad, Sasaki Koji, Larson Dirk R, Garcia-Manero Guillermo, Onida Francesco, Gangat Naseema, Montalban-Bravo Guillermo, Patnaik Mrinal M
Abstract excerpt
ABSTRACT: We sought to develop a survival model in chronic myelomonocytic leukemia (CMML) that is primarily based on clinical variables and examine additional impact from mutations and karyotype. A total of 457 molecularly annotated patients were considered. Multivariable analysis identified circulating blasts ≥2% (1 point), leukocytes ≥13 × 109/L (1 point), and severe (2 points) or moderate (1 point) anemia as...
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