Article
Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA-histone interactions.
Nucleic acids research - 28 Oct 2024
Ding Dongbo, Pang Matthew Y H, Deng Mingxi, Nguyen Thi Thuy, Liu Yue, Sun Xulun, Xu Zhichun, Zhang Yingyi, Zhai Yuanliang, Yan Yan, Ishibashi Toyotaka
Abstract excerpt
Multiple testis-specific histone variants are involved in the dynamic chromatin transitions during spermatogenesis. H2B.W1 (previously called H2BFWT) is an H2B variant specific to primate testis with hitherto unclear functions, although its single-nucleotide polymorphisms (SNPs) are closely associated with male non-obstructive infertility. Here, we found that H2B.W1 is only expressed in the mid-late spermatogonia...
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