Single nucleotide polymorphism at 5' UTR of H2BC1 and promoter methylation influence TSH2B expression.

doi:10.1530/REP-24-0382

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Article

Single nucleotide polymorphism at 5' UTR of H2BC1 and promoter methylation influence TSH2B expression.

Reproduction (Cambridge, England) - 1 May 2025

Patankar Aniket, Joshi Kairavi, Sudhakar Digumarthi V S, Gajbhiye Rahul, Surve Suchitra, Parte Priyanka

Abstract excerpt

In brief: The transition from histones to protamines during spermiogenesis is critical for male genome integrity and influences fertilisation and early embryogenesis. This study reveals that specific 5' UTR single nucleotide polymorphisms (SNPs) and promoter methylation of the H2BC1 gene may regulate TSH2B expression in sperm, contributing new insights into the regulatory mechanisms of testis-specific genes and...

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Share to 5' Untranslated Regions
Share to DNA Methylation
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infertility, Male

Share to Promoter Regions, Genetic

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Open in PubMed

Identifiers

PMID: 40146916
DOI: 10.1530/REP-24-0382

Genes

H2BC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.