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Article

Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and Desflurane.

Journal of cardiovascular pharmacology - 1 May 2017

Harisseh Rania, Chiari Pascal, Villedieu Camille, Sueur Pauline, Abrial Maryline, Fellahi Jean-Luc, Ovize Michel, Gharib Abdallah

Abstract excerpt

BACKGROUND: Volatile anesthetics are known to limit myocardial ischemia-reperfusion injuries. Mitochondria were shown to be major contributors to cardioprotection. Cyclophilin D (CypD) is one of the main regulators of mitochondria-induced cell death. We compared the effect of isoflurane, sevoflurane, and desflurane in the presence or absence of CypD, to clarify its role in the mechanism of cardioprotection...

Read the complete abstract on PubMed

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Share to Anesthetics, Inhalation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Potential, Mitochondrial

Share to Mitochondria, Heart

Share to Myocardial Reperfusion Injury

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Source

Identifiers

PMID: 28328748
DOI: 10.1097/FJC.0000000000000479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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