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The iron chelator deferasirox affects redox signalling in haematopoietic stem/progenitor cells

30 Mar 2015

Abstract excerpt

The iron chelator deferasirox (DFX) prevents complications related to transfusional iron overload in several haematological disorders characterized by marrow failure. It is also able to induce haematological responses in a percentage of treated patients, particularly in those affected by myelodysplastic syndromes. The underlying mechanisms responsible for this feature, however, are still poorly understood. In...

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PMID: 25825160
DOI: 10.1111/bjh.13381

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