Article
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2024
Huang Guanyu, Zhang Jiajun, Xu Yu, Wu Fei, Fu Yiwei, Zhang Xuelin, Yin Hanxiao, You Yuanyuan, Zhao Peng, Liu Weihai, Shen Jingnan, Yin Junqiang
Abstract excerpt
LACTB is identified as a tumor suppressor in several tumors. However, preliminary study reveals that LACTB is overexpressed in osteosarcoma and indicates poor prognosis. Two missense mutations (rs34317102 and rs2729835) exist simultaneously in 92.31% of osteosarcoma patients and cause M5L and R469K double mutations in LACTB, suggesting the biologic function of LACTB protein may be altered in osteosarcoma....
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