Article
Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.
Cell death and differentiation - 1 Nov 2015
Zhao Y, Zhang C, Yue X, Li X, Liu J, Yu H, Belyi V A, Yang Q, Feng Z, Hu W
Abstract excerpt
Tumor-suppressor p53 is frequently mutated in human cancers. Many tumor-associated mutant p53 (mutp53) proteins gain new functions in promoting tumorigenesis, defined as gain-of-function (GOF). The mechanisms for mutp53 GOF are not well understood. Here, we report Pontin, a highly conserved AAA+ ATPase important for various cellular functions, as a new mutp53-binding protein. This Pontin-mutp53 interaction...
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