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Article

Complex structural variations functionally inactivate the telomerase chaperone TCAB1 in osteosarcoma.

BMC cancer - 4 Jun 2026

Keegan Joshua, Sorbello Sydney, Mori Joakin, Muratani Shugo, Leshchiner Ignaty, Heaphy Christopher M, Flynn Rachel L

Abstract excerpt

Activation of the alternative lengthening of telomeres (ALT) pathway accounts for cellular immortalization in 75% of pediatric osteosarcoma. ALT does not rely on a single enzyme but instead, catalyzes telomere elongation via homologous recombination. There has been steady progress in defining the mechanisms that regulate the ALT pathway. However, the spectrum of genetic mutations that underlie activation of ALT...

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Share to Bone Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42243724
DOI: 10.1186/s12885-026-16250-5
PMCID: PMC13455141

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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