Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers.

Scientific reports - 10 Jun 2016

Liao Hsien-Feng, Lee Hsien-Hsiung, Chang Ya-Sian, Lin Chia-Li, Liu Ting-Yuan, Chen Yu-Chia, Yen Ju-Chen, Lee Ya-Ting, Lin Chien-Yu, Wu Shih-Hsiung, Ko Ying-Chin, Chang Jan-Gowth

Abstract excerpt

The ALPK1 gene located in the 4q25 region encodes a newly explored protein kinase which could phosphorylate the amino acid of a domain full of α-helices. Recently, several studies have indicated that the expression of ALPK1 is related to inflammation and various diseases; therefore, the purpose of this investigation was to determine whether the expression of ALPK1 has an influence on tumorigenesis and to further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Down-Regulation

Share to Gene Knockdown Techniques

Share to Inflammation

Share to Protein Kinases

Share to Taiwan

Source

Open in PubMed Open full text

Identifiers

PMID: 27283888
DOI: 10.1038/srep27350
PMCID: PMC4901299

Genes

ALPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers.PMID 27283888Read ↗

A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.Semantic proximity Read ↗

LAPTM4B: an oncogene in various solid tumors and its functions.Semantic proximity Read ↗

Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancerSemantic proximity Read ↗

ALPK1 genetic regulation and risk in relation to gout.Semantic proximity Read ↗

A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1.Semantic proximity Read ↗

Rare missense variants in the ALPK1 gene may predispose to periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndromeSemantic proximity Read ↗

Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.Semantic proximity Read ↗

Disease-associated mutations in conserved residues of ALK-1 kinase domainSemantic proximity Read ↗

Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancerSemantic proximity Read ↗

MicroRNA Binding Site Polymorphisms of the Long-Chain Noncoding RNA MALAT1 are Associated with Risk and Prognosis of Colorectal Cancer in Chinese Han Population.Semantic proximity Read ↗

SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.Semantic proximity Read ↗

Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine‐zipper domainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.