Article
LAPTM4B polymorphism is associated with non‑small cell lung cancer susceptibility and prognosis.
Oncology reports - 1 May 2014
Tang Han, Tian Hui, Yue Weiming, Li Lin, Li Shuhai, Gao Cun, Si Libo, Qi Lei, Lu Ming, Hu Wensi
Abstract excerpt
Lysosome-associated protein transmembrane-4β (LAPTM4B) is a novel cancer-related gene that is upregulated in many tumors, and which plays important roles in carcinogenesis. It has two alleles, LAPTM4B 1 and LAPTM4B 2. LAPTM4B 1 contains only one copy of a 19-bp sequence in the first exon, whereas LAPTM4B 2 contains two tight tandem segments. Previous studies have shown that LAPTM4B 2 is a risk factor for...
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