Article
Development of a method for the imputation of the multi-allelic serotonin-transporter-linked polymorphic region (5-HTTLPR) in the Japanese population.
Journal of human genetics - 1 Jan 2025
Yanagida Yutaro, Naka Izumi, Nakachi Yutaka, Ikegame Tempei, Kasai Kiyoto, Kajitani Naoto, Takebayashi Minoru, Bundo Miki, Ohashi Jun, Iwamoto Kazuya
Abstract excerpt
Serotonin-transporter-linked polymorphic region (5-HTTLPR), a variable number of tandem repeats in the promoter region of serotonin transporter gene, is classified into short (S) and long (L) alleles. Initial case-control association studies claiming the risks of the S allele in depression and anxiety were not completely supported by recent studies. However, most studies, especially those on East Asian...
Topics
- Humans
- Alleles
- East Asian People
- Gene Frequency
- Genotype
- Japan
- Polymorphism, Single Nucleotide
- Serotonin Plasma Membrane Transport Proteins