Article
Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures.
Biological psychiatry - 1 Sept 2009
Wray Naomi R, James Michael R, Gordon Scott D, Dumenil Troy, Ryan Leanne, Coventry William L, Statham Dixie J, Pergadia Michele L, Madden Pamela A F, Heath Andrew C, Montgomery Grant W, Martin Nicholas G
Abstract excerpt
BACKGROUND: The length polymorphism repeat in the promoter region of the serotonin transporter gene (5HTTLPR) is one of the most studied polymorphisms for association with a range of psychiatric and personality phenotypes. However, the original 5HTTLPR assay is prone to bias toward short allele calling. METHODS: We designed new assays for the 5HTTLPR suitable for large-scale genotyping projects and we genotyped...
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