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Article

A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes.

European journal of human genetics : EJHG - 1 May 2022

Majumdar Arunabha, Patel Preksha, Pasaniuc Bogdan, Ophoff Roel A

Abstract excerpt

In genetic studies of psychiatric disorders in the pre-genome-wide association study (GWAS) era, one of the most commonly studied loci is the serotonin transporter (SLC6A4) promoter polymorphism, a 43-base-pair insertion/deletion polymorphism in the promoter region (5-HTTLPR). The genetic association signals between 5-HTTLPR and psychiatric phenotypes, however, have been inconsistent across many studies. Since...

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Identifiers

PMID: 34949768
DOI: 10.1038/s41431-021-00996-6
PMCID: PMC9091198

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