Article
Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project.
BMC genomics - 24 Jul 2018
Yasuda Jun, Katsuoka Fumiki, Danjoh Inaho, Kawai Yosuke, Kojima Kaname, Nagasaki Masao, Saito Sakae, Yamaguchi-Kabata Yumi, Tadaka Shu, Motoike Ikuko N, Kumada Kazuki, Sakurai-Yageta Mika, Tanabe Osamu, Fuse Nobuo, Tamiya Gen, Higasa Koichiro, Matsuda Fumihiko, Yasuda Nobufumi, Iwasaki Motoki, Sasaki Makoto, Shimizu Atsushi, Kinoshita Kengo, Yamamoto Masayuki
Abstract excerpt
BACKGROUND: Genotype imputation from single-nucleotide polymorphism (SNP) genotype data using a haplotype reference panel consisting of thousands of unrelated individuals from populations of interest can help to identify strongly associated variants in genome-wide association studies. The Tohoku Medical Megabank (TMM) project was established to support the development of precision medicine, together with the...
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