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Article

Japanese Cohort Study and Meta-Analysis Demonstrate Significant Association Between Serotonin Transporter-Linked Polymorphic Region and Schizophrenia.

Neuropsychopharmacology reports - 1 Jun 2026

Miyachi Masao, Shirai Toshiyuki, Okada Shohei, Minami Kiriko, Tsukamoto Ryo, Mouri Kentaro, Okazaki Satoshi, Otsuka Ikuo, Hishimoto Akitoyo

Abstract excerpt

Schizophrenia is a prevalent psychiatric disease that substantially affects health and increases mortality risk. The 5-hydroxytryptamine system has been implicated in its pathogenesis. The SLC6A4 gene encodes the serotonin transporter, which regulates synaptic 5-hydroxytryptamine through reuptake into presynaptic neurons. Within its promoter region, there is a 44-base pair insertion/deletion polymorphism, known...

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Identifiers

PMID: 41905965
DOI: 10.1002/npr2.70114
PMCID: PMC13581099

Genes

SLC6A4

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