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Article

Japanese Cohort Study Identifies an Association Between the Serotonin Transporter-Linked Polymorphic Region and Suicide Death.

Neuropsychopharmacology reports - 1 Jun 2026

Okada Shohei, Shirai Toshiyuki, Miyachi Masao, Yamasaki Gentaro, Minami Kiriko, Tsukamoto Ryo, Mouri Kentaro, Tanifuji Takaki, Katada Ryuichi, Okazaki Satoshi, Otsuka Ikuo, Hishimoto Akitoyo

Abstract excerpt

INTRODUCTION: More than 720 000 individuals die by suicide annually worldwide, making it a major public health concern and a leading cause of death among young people, particularly in Asian populations. Dysregulation of the 5-hydroxytryptamine system has been implicated in suicide risk. The SLC6A4 gene encodes the serotonin transporter, which regulates synaptic 5-hydroxytryptamine levels. Its promoter region...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41968640
DOI: 10.1002/npr2.70120
PMCID: PMC13071177

Genes

SLC6A4

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