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Article

Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models.

European thyroid journal - 1 Oct 2024

Hu Yalan, Soares De Oliveira Lorraine, Falize Kim, Paul van Trotsenburg A S, Fliers Eric, Kaserman Joseph E, Wilson Andrew A, Hollenberg Anthony N, Bruinstroop Eveline, Boelen Anita

Abstract excerpt

Background: Mutations in TBL1X, part of the NCOR1/SMRT corepressor complex, were identified in patients with hereditary X-linked central congenital hypothyroidism and associated hearing loss. The role of TBL1X in thyroid hormone (TH) action, however, is incompletely understood. The aim of the present study was to investigate the role of TBL1X on T3-regulated gene expression in two human liver cell models....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39316725
DOI: 10.1530/ETJ-24-0162
PMCID: PMC11558919

Genes

TBL1X
CPT1A
KLF9
PCK1
TH
DIO1
ELOVL2
FBP1
G6PC1
HMGCS2
NCOR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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