Article

LHX3 promotes EMT process in hepatoma cell through β-catenin/TCF4 pathway

2024-12-12

Abstract excerpt

<title>Abstract</title> <p>Hepatic carcinoma (HCC) is a highly malignant cancer and lacks effective therapeutic targets. The role of LHX3 has been extensively studied in various tumor tissues, where it has been identified as a promoter of tumorigenesis and malignancy. However, the specific functional role and potential mechanism of LHX3 in human HCCs are not clearly clarified. We found that LHX3 was overexpressed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aafef2b1-2610-5df0-b233-1e8482a69d63
DOI: 10.21203/rs.3.rs-5165345/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LHX3 promotes EMT process in hepatoma cell through β-catenin/TCF4 pathwayDOI 10.21203/rs.3.rs-5165345/v1Read

TOX3 drives hepatocellular carcinoma progression by suppressing the p53-p21-Rb pathwaySemantic proximity Read

CBX3 Regulated by miR-139 Promoted the Development of HCC by Regulating Cell Cycle ProgressionSemantic proximity Read

CBX3 regulated by miR-139 promoted the development of HCC by regulating cell cycle progressionSemantic proximity Read

ETV4 mediates the Wnt/β-catenin pathway through transcriptional activation of ANXA2 to promote hepatitis B virus-associated liver hepatocellular carcinoma progressionSemantic proximity Read

Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.Semantic proximity Read

The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCCSemantic proximity Read

NANOG promotes liver cancer cell invasion by inducing epithelial–mesenchymal transition through NODAL/SMAD3 signaling pathwaySemantic proximity Read

Oct4 induces EMT through LEF1/β-catenin dependent WNT signaling pathway in hepatocellular carcinomaSemantic proximity Read

LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axisSemantic proximity Read

LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin PathwaysSemantic proximity Read

PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cellsSemantic proximity Read

H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.Semantic proximity Read