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Tau accumulation is cleared by the induced expression of VCP via autophagy

24 Sept 2024

Abstract excerpt

Tauopathy, including frontotemporal lobar dementia and Alzheimer’s disease, describes a class of neurodegenerative diseases characterized by the aberrant accumulation of Tau protein due to defects in proteostasis. Upon generating and characterizing a stable transgenic zebrafish that expresses the human TAU P301L mutant in a neuron-specific manner, we found that accumulating Tau protein was efficiently cleared via...

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PMID: 39316141
DOI: 10.1007/s00401-024-02804-z

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