Article

A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer Disease

2024-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Selective elimination of early pathological TAU species may be a promising therapeutic strategy to reduce TAU accumulation that contributes to neurodegeneration and hallmarks Alzheimer disease (AD). By performing a genetic analysis of a cohort of 435 patients with AD, we defined the NDP52 GE variant (rs550510) of the autophagic receptor NDP52 (also known as CALCOCO2) as a protective factor for AD...

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Literature Corpus work: 2862af9f-7dda-5719-a738-b35dcaf93728
DOI: 10.1101/2024.08.13.24311780

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