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Article

Growth defect of domain III glycoprotein B mutants of human cytomegalovirus reverted by compensatory mutations co-localizing in post-fusion conformation.

mBio - 16 Oct 2024

Mollik Madlen, Rohorzka Andreas, Chen Xiaohan, Kropff Barbara, Eisler Lukas, Külekci Büsra, Puchhammer-Stöckl Elisabeth, Thomas Marco, Görzer Irene

Abstract excerpt

Cell entry is a crucial step for a virus to infect a host cell. Human cytomegalovirus utilizes glycoprotein B (gB) to fuse the viral and host cell membranes upon receptor binding of gH/gL-containing complexes. Fusion is mediated by major conformational changes of gB from a metastable pre-fusion to a stable post-fusion state whereby the central trimeric coiled-coils, formed by domain (Dom)III α helices, remain...

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Identifiers

PMID: 39315800
DOI: 10.1128/mbio.01812-24
PMCID: PMC11481916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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