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Differences in Growth Properties among Two Human Cytomegalovirus Glycoprotein O Genotypes

22 Aug 2017

Abstract excerpt

Glycoprotein O (gO) of the human cytomegalovirus (HCMV) is the critical subunit of the envelope trimer gH/gL/gO as it interacts with platelet-derived growth factor alpha receptor upon fibroblast entry, and triggers gB-mediated fusion for fibroblast and epithelial cell infection. Eight genotypes (GT) of the highly polymorphic gO gene are described, yet it is unclear whether the distinct GTs differ in their...

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PMID: 28878758
DOI: 10.3389/fmicb.2017.01609

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